Selleck Chemicals/Tofacitinib（CP-690550）/S2789-免疫在线蚂蚁淘旗下平台

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商品详细Selleck Chemicals/Tofacitinib（CP-690550）/S2789

Selleck Chemicals/Tofacitinib（CP-690550）/S2789

商品编号： S2789

品牌： Selleck Chemicals

市场价： ¥7400.00

美元价： 4440.00

产地：美国(厂家直采)

公司：

产品分类：多肽合成

公司分类： peptide

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Description

Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.

Targets

JAK3 ^[1](Cell-free assay)	JAK2 ^[1](Cell-free assay)	JAK1 ^[1](Cell-free assay)
1 nM	20 nM	112 nM

In vitro

CP-690550 is a specific, orally inhibitor of JAK3, it is 20- to 100-fold less potent for JAK2 and JAK1 with IC50 of 20 nM and 112 nM, respectively. CP-690550 doesn"t have potent activity against 30 other kinases (all median IC50 > 3000 nM). CP-690,550 inhibits IL-2–induced proliferation with 30-fold greater potency than its effects on GM-CSF–induced proliferation. ^[1] CP-690550 effectively inhibits a murine mixed lymphocyte reaction (MLR) (IC50 = 91 nM). ^[2] CP-690550 potently inhibits IL-4 induced upregulation of CD23 (IC50=57 nM) and class II major histocompatibility complex (MHCII) expression (IC50=71 nM) on murine B cells. ^[3] A recent research indicates low dose of CP-690550 accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
T cells	MVTGeY5kfGmxbjDBd5NigQ>?	NX TJhEOC5zL{CuN{8yKM7:TR?=	NVTqc2NZOjRiaB?=	NGLGfFVlcXO{dYD0d{DPu2NvY3jhbY4h[3m2b3vpcoUhe2mpbnHsbY5o	NGUWYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{MUO4N\|I1OSd-MkGzPFMzPDF:L3G+
CD4+T	NXXqPIZVTnWwY4Tpc44hSXO\|YYm=	NVvUTVJOOTByIH7N	M4TNdlI1NzR6IHi=	NUSweI1R[WK{b3fheIV{KEOGMz3pcoR2[2WmIIDoc5NxcG:{eXzheIlwdiCxZjDTWGFVew>?	MX68ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh6NEW4NEc,OjF6OES1PFA9N2F-
CD4+T	MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoW4NVAxNzVyMDDuUS=>	MljIOFghcA>?	M4T2S4lvcGmkaYTzJIFvfGlvQ1SzMYlvHWlZXSgR2Q1M8LiVDDj[YxtKHC{b3zp[oVz[XSrb36=	M3LsdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJzOEi0OVgxLz5{MUi4OFU5ODxxYU6=
CD4+T	MorxSpVv[3Srb36gRZN{[Xl?	NGKwWo4zOC9zMECvOVAxKG6P	NV3PUHZJPDhiaB?=	M4jwfolvcGmkaYTzJJRpSCuZYlcJMhd2ZiIFnMMVQtKEmITj5Ot{whUUxvMUfBJIFvCCLTD2yNi=>	NF7F[\|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{MUi4OFU5OCd-MkG4PFQ2QDB:L3G+
Sf9	MkjVSpVv[3Srb36gZZN{[Xl?		Ml;JN\|AhdWmwcx?=	MoHaTY5pcWKrdHnvckBwiCqdX3hckBIW1RvZoXz[YQhUkGNMzDjZZRidHm2aXOg[I9u[WmwIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2ey2rbnlZ5RmCCVZkmgZ4VtdHNidYPpcocheG:ueXfseZRidWmlIHHjbYQufHm{b4PpcoUh[XNic4Xid5Rz[XSnIHHmeIVzKDNyIH3pcpMh[nliRVzJV2EtKEurIE2gNE4xODB2IN88UU4>	M1;EbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ\|Nk[4OFg1Lz5{M{[2PFQ5PDxxYU6=
Sf9	NF;jfIhHfW6ldHnvckBie3OjeR?=		NXHrUXVRQTBibXnudy=>	NX:5cpdRUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDOMZRmem2rbnHsJGdUXC22YXfn[YQhUkGNMzDlfJBzXO\|ZXSgbY4hW2Z7IHPlcIx{KHW\|aX7nJGJqd3Srbj3MR{1GWUWGRWDFS2R[TkWZTFWgZZMhe3Wkc4TyZZRmKGGodHXyJFkxKG2rboOgZpkhXFJvRmLFWEBie3OjeTygTWM2OCB;IECuNFAxPiEQvF2u	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB6N{e1NEc,OjJyOEe3OVA9N2F-
Sf9	MlKSpVv[3Srb36gZZN{[Xl?		NGfw[nc{OCCvaX7z	MVnJcohq[mm2aX;uJI9nKGi3bXHuJGdUXC2odYPl[EBLSUtzIHPheIFtgXSrYzDkc41icW5iZYjwdoV{e2WmIHnuJIJi[3Wub4pdpV{NWmwZnXjeIVlKFOoOTDj[YxteyC3c3nu[{Bxd2y7Z3z1eIFucWNiYXPp[E11gXKxc3nu[UBieyC\|dXLzeJJifGViYX[ZIhOzBibXnud{BjgSCHTFnTRUwhU2liPTCwMlAxODdizszNMi=>	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ4OES4OEc,OjN4Nki0PFQ9N2F-
Sf9	M1vmVmZ2dmO2aX;uJIF{e2G7		NFvCbYQ{OCCvaX7z	M1nuPWlvcGmkaYTpc44hd2ZiaIXtZY4hT1OWLX1d4VlKEqDS{KgZ4F1[Wy7dHnjJIRwdWGrbjDlfJBzXO\|ZXSgbY4h[mGldXzveolzfXNvaX7m[YN1WRiU3[5JINmdGy\|IIXzbY5oKHCxbInncJV1[W2rYzDhZ4llNXS7cn;zbY5mKGG\|IIP1ZpN1emG2ZTDh[pRmeiB\|MDDtbY5{KGK7IFXMTXNCNCCNaTC9JFAvODByNzFOwG0v	MoHnQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4Nki0PFQoRjJ\|Nk[4OFg1RC:jPh?=
Sf9	M4HN[mZ2dmO2aX;uJIF{e2G7			M1;PTmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiR2PUMZRi2enZDDKTFEhG:vYXnuJEg4QDVidH:xNVI2MSCxZjDKRWs{KGW6cILld5NmCCrbjDpcpNm[3RiU3[5JINmdGy\|IHL5JGVNUVODLDDJR\|UxKD1iMD6wNFEh\|ryPLh?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV7M{G4Nkc,OTR3OUOxPFI9N2F-
Sf9	NHrwfWFHfW6ldHnvckBie3OjeR?=			NWrYOnh{UW6qaXLpeIlwdiCxZjDHV3QufGGpZ3XkJIh2dWGwIFrBT\|Mh[2G2YXz5eIlkKGSxbXHpckBmgHC{ZYPz[YQhcW5iU3[5JINmdGy\|IHL5JGVNUVODLDDJR\|UxKD1iMD6wNFEh\|ryPLh?=	NHvpdGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{MUGwOVcyOSd-MkGxNFU4OTF:L3G+
Sf9	NWjuVFhoTnWwY4Tpc44h[XO\|YYm=		MlmxPVAhdWmwcx?=	NFjWdVRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IF6teIVzdWmwYXygS3NVNXSjZ3fl[EBLSUtzIHX4dJJme3OnZDDpckBUjliY3XscJMhfXOrbnegRolwfGmwLVzDMWVSTUSHUFXHSHlHTVeORTDhd{B{fWK\|dILheIUh[W[2ZYKgPVAhdWmwczDifUBVWi2IUlXUJIF{e2G7LDDJR\|UxKD1iMD6wNFMh\|ryPLh?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB6N{e1NEc,OjJyOEe3OVA9N2F-
Sf9	M1jwTWZ2dmO2aX;uJIF{e2G7			MWTJcohq[mm2aX;uJI9nKEeVVD30ZYdoWRiaIXtZY4hUkGNMzDjZZRidHm2aXOg[I9u[WmwIHX4dJJme3OnZDDpckBUjliY3XscJMh[nliRVzJV2EtKEmFNUCgQUAxNjByM{Og{txONg>?	Mn;qQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMEW3NVEoRjJzMUC1O\|EyRC:jPh?=
Sf9	M1fvdmZ2dmO2aX;uJIF{e2G7		MkTyPVAhdWmwcx?=	MV;Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KE5vdHXycYlv[WxiR2PUMZRi2enZDDKRWszKGW6cILld5NmCCrbjDT[lkh[2WubIOgeZNqdmdiQnnveIlvNUyFLVXRSWRGWEWJRGnGSXdNTSCjczDzeYJ{fHKjdHWgZYZ1XJiOUCgcYlveyCkeTDUVk1HWkWWIHHzd4F6NCCLQ{WwJF0hOC5yMESg{txONg>?	M3i4fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ{MEi3O\|UxLz5{MkC4O\|c2ODxxYU6=
SF21	NEi3WoFHfW6ldHnvckBie3OjeR?=		MXWxNEBucW6\|	NUTKdGp6UW6qaXLpeIlwdiCxZjDKRWszKCi3bnvuc5dvKG:{aXfpckkhXiycnXzd4VlKGmwIGPGNlEh[2WubIOgeZNqdmdiQnnveIlvNUuDSVXUSGtGYVmWVlvEJIF{KHO3YoP0doF1SCjbnSgX\|M{WGejbX3hYWFVWCCrbnP1ZoF1WRiZn;yJFExKG2rboOgdJJqd3JidH:gd5Vje3S{YYTlJIFlGm2aX;uJI1m[XO3cnXkJIFnfGW{IEOwJI1qdnNiYomgWI9x[2:3boSgZY5idHm\|aYOsJGlEPTBiPTCwMlAxPCEQvF2u	NIDud3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{M{W0NVY4OCd-MkO1OFE3PzB:L3G+
insect cells	NWLkTldRTnWwY4Tpc44h[XO\|YYm=			M37YNGlvcGmkaYTpc44hd2ZiR2PUMZRi2enZDDKZYsyKGW6cILld5NmCCrbjDpcpNm[3RiY3XscJMhfXOrbnegO\|AhfU1iQWTQMEBKSzVyIE2gNE4xODZzIN88UU4>	NGqy[Ic9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{MUG1OVYxPSd-MkGxOVU3ODV:L3G+
insect cells	M{W3d2Z2dmO2aX;uJIF{e2G7			MnnQTY5pcWKrdHnvckBwiCJU2SteIFo2WmIFrhb\|MhXiycnXzd4VlKGmwIHnud4VkfCClZXzsd{B2e2mwZzCxPEB2VSCDVGCsJGlEPTBiPTCwMlAxQCEQvF2u	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF3NU[wOUc,OjFzNUW2NFU9N2F-
T-cells	MYGeY5kfGmxbjDhd5NigQ>?		NXy3RmdoPzJiaILz	NUX4PZRNUW6qaXLpeIlwdiCxZjDJUFIucW6mdXPl[EBxem:uaXldoF1cW:wIH;mJIh2dWGwIGSgZ4VtdHNiYYPz[ZN{WRiYYOgX\|NJZXSqeX3p[IlvSCrbnPvdpBwemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCLQ{WwJF0hOC5yMUGg{txONg>?	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV7M{G4Nkc,OTR3OUOxPFI9N2F-
insect cells	NGfMcllHfW6ldHnvckBie3OjeR?=			NEDy[mhKdmirYnn0bY9vKG:oIFfTWE11[WepZXSgToFsOiCneIDy[ZN{WRiaX6gbY5{WO2IHPlcIx{KHW\|aX7nJFIxKHWPIFHUVEwhUUN3MDC9JFAvODF{IN88UU4>	MV68ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF3NU[wOUc,OjFzNUW2NFU9N2F-
MO7	NID1S4dHfW6ldHnvckBie3OjeR?=			Mnu4TY5pcWKrdHnvckBwiCMYXuzMY1mGmjdHXkJGlNOTVvaX7keYNmCCVdHH0OUBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gUW84KGOnbHzzJIJ6KGOnbHytZoF{WRiYYPzZZktKEmFNUCgQUAxNjB{NDFOwG0v	MknaQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzNUW2NFUoRjJzMUW1OlA2RC:jPh?=
Ba/F3	NYP3T5ExTnWwY4Tpc44h[XO\|YYm=		NXLETmlZPjBibXnudy=>	M1zwfmlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIFrBT\|EhXiycnXzd4VlKGmwIFLhM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gV3RCXDVicHjvd5Bpd3K7bHH0bY9vKGGodHXyJFYxKG2rboOgZpkhSWyyaHHTZ5JmW5iYYPzZZktKEmFNUCgQUAxNjB{NjFOwG0v	M4DNe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ{MEi3O\|UxLz5{MkC4O\|c2ODxxYU6=
T-cells	MnPQSpVv[3Srb36gZZN{[Xl?			M37FZmlvcGmkaYTpc44hd2ZiSlHLN{8yKGmwIHj1cYFvKFRiY3XscJMhXiycnXzd4lvyCFREOgZZN{XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDJUFIue3SrbYXsZZRmCCVVFHUOYEheGixc4Doc5J6dGG2aX;uMEBKSzVyIE2gNE4xOjhizszNMi=>	NEacJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{M{W0NFY1QCd-MkO1OFA3PDh:L3G+
PBMC	M2fpOGZ2dmO2aX;uJIF{e2G7			MULJcohq[mm2aX;uJGlNNTdvaX7kZ5VmCCVVFHUOUBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gVGJOSyClZXzsd{BjgSCobH;3JIN6fG:vZYTyfUwhUUN3MDC9JFAvODN7IN88UU4>	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{N{SyN{c,OjZ7Mke0NlM9N2F-
TF1	MYHGeY5kfGmxbjDhd5NigQ>?		NEHKco8zOCCvaX7z	Mli1TY5pcWKrdHnvckBwiCMQVuxJIlvKGi3bXHuJHRHOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNPi2rbnT1Z4VlKFOWQWSzJJBpd3OyaH;yfYxifGmxbjDpcoN2[mG2ZXSg[o9zKDJyIH3pcpMhm:ubH;3[YQh[nliSVy2JINp[WyuZX7n[UBnd3JiM{CgcYlveyCrbjDwdoV{W6lZTDv[kB4cG:uZTDicI9wCxiRVO1NEA:KDBwMESzJO69VS5?	M3jMSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ\|NkW5NlE1Lz5{M{[1PVIyPDxxYU6=
TF1	NX3kXoRwTnWwY4Tpc44h[XO\|YYm=			MXTJcohq[mm2aX;uJI9nKEqDS{GgbY4hcHWvYX6gWGYyKGOnbHzzJIF{e2W\|c3XkJIF{KHO3cIDy[ZN{cW:wIH;mJGlNPi2\|dHnteYxifGWmIGPURXQ{KHCqb4PwbI9zgWyjdHnvckBjgSCDbIDoZXNkemWnbjDhd5NigSxiSV7IJF0hOC5yNEWg{txONg>?	M2DvOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ4M{eyOlU{Lz5{NkO3NlY2OzxxYU6=
CTLL	NFXXdHpHfW6ldHnvckBie3OjeR?=			MVLJcohq[mm2aX;uJI9nKEqja{OtcYVlcWG2ZXSgTWwzNWmwZIXj[YQhW3SjdEWgdIhwe3Cqb4L5cIF1cW:wIHnuJI1wfXOnIFPUUGwh[2WubIOgZpkh[2WubD3iZZNmCCjc4PhfUwhUUN3MDC9JFAvODR6IN88UU4>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF3NU[wOUc,OjFzNUW2NFU9N2F-
Sf9	NYnGeolZTnWwY4Tpc44h[XO\|YYm=		MWm5NEBucW6\|	M324cmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiTj30[ZJucW6jbDDHV3QufGGpZ3XkJHR[UzJiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{B2e2mwZzDCbY91cW5vTFOtSXFGTEWSRVfEXWZGX0yHIHHzJJN2[nO2cnH0[UBi SncjC5NEBucW6\|IHL5JHRTNU[URWSgZZN{[XluIFnDOVAhRSByLkC1NkDPxE1w	NH23dYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{MkC4O\|c2OCd-MkKwPFc4PTB:L3G+
TF1	MmntSpVv[3Srb36gZZN{[Xl?			MmrnTY5pcWKrdHnvckBwiCMQVuxJIlvKGi3bXHuJHRHOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNOi2rbnT1Z4VlKFOWQWSzJJBpd3OyaH;yfYxifGmxbjygSWM2OCB;IECuNFU{KM7:TT6=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV7MUSwNkc,OjJ3OUG0NFI9N2F-
TF1	NWf0dmhNTnWwY4Tpc44h[XO\|YYm=		M13WlIxKG2rboO=	MoTFTY5pcWKrdHnvckBwiCMQVuxJIlvKGi3bXHuJHRHOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNPi2rbnT1Z4VlKFOWQWSzJJBpd3OyaH;yfYxifGmxbjDpcoN2[mG2ZXSg[o9zKDJyIH3pcpMheHKrb4KgeI8hUUx4LXnu[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB\|MDD0c{A1PSCvaX7zMEBGSzVyIE2gNE4xPTNizszNMi=>	NHjtfY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{Mk[5PFA5PCd-MkK2PVgxQDR:L3G+
TF1	M1vLbmZ2dmO2aX;uJIF{e2G7		NWnWXIZGOjBibXnudy=>	MX7Jcohq[mm2aX;uJI9nKEqDS{GgbY4hcHWvYX6gWGYyKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gTWw3NWmwZIXj[YQhW1SDVEOgdIhwe3Cqb4L5cIF1cW:wIHnuZ5Vj[XSnZDDmc5IhOjBibXnud{Bnd2yub4fl[EBjgSCLTE[gZ4hidGynbnflJIZweiB\|MDDtbY5{NCCHQ{WwJF0hOC5yNUOg{txONg>?	M4HhN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ\|NkW5NlE1Lz5{M{[1PVIyPDxxYU6=
Ba/F3	MYTGeY5kfGmxbjDhd5NigQ>?		MmLCOlAhdWmwcx?=	MnzTY5pcWKrdHnvckBwiCWRVyt[pV{WRiSlHLN{BmgHC{ZYPz[YQhcW5iQnGvSlMh[2WubIOgZZN{XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDTWGFVPSCyaH;zdIhwenmuYYTpc44h[W[2ZYKgOlAhdWmwczDifUBCdHCqYWPjdoVmdiCjc4PhfUwhUUN3MDC9JFAvODV2IN88UU4>	MnLxQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOEe3OVAoRjJ{MEi3O\|UxRC:jPh?=
T-cells	M3i0U2Z2dmO2aX;uJIF{e2G7			NWT6OoIyUW6qaXLpeIlwdiCxZjDhcIxw2WwaXOgZ4VtdHNvc4TpcZVt[XSnZDDwdo9tcW[ncnH0bY9vKGmwIH3vcotmgSCWIHPlcIx{KGK7IH3pfIVlKGy7bYDoc4N6fGVicnXhZ5Rqd25ibXX0bI9lNCCLQ{WwJF0hOC5yNUeg{txONg>?	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV7M{G4Nkc,OTR3OUOxPFI9N2F-
CD34+	NH3VUndHfW6ldHnvckBie3OjeR?=			NFfuN\|hKdmirYnn0bY9vKG:oIFrBT\|IhcW5iaIXtZY4hS0R\|NDugZ4VtdHNiYYPz[ZN{WRiYYOgbY5pcWKrdHnvckBwiCHUF:tcYVlcWG2ZXSgZ4VtdCCycn;sbYZmemG2aX;uMEBKSzVyIE2gNE4xPzFizszNMi=>	M2DTOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ4OUK3OFI{Lz5{NkmyO\|QzOzxxYU6=
TF1	NFOydVdHfW6ldHnvckBie3OjeR?=			MVHJcohq[mm2aX;uJI9nKEmOND3pcoR2[2WmIIDyc4xqmW{YYTpc44hd2ZiVF[xJINmdGy\|LDDJR\|UxKD1iMD6wPEDPxE1w	Mn35QIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7M{S0OVcoRjF4OUO0OFU4RC:jPh?=
T-cells	NHvUNY5HfW6ldHnvckBie3OjeR?=			NVu0eW5LUW6qaXLpeIlwdiCxZjDhcIxw2WwaXOgZ4VtdHNvc4TpcZVt[XSnZDDwdo9tcW[ncnH0bY9vKGmwIHj1cYFvKFRiY3XscJMh[nlibXn4[YQhdHmvcHjvZ5l1SC{ZXHjeIlwdiCvZYToc4QtKEmFNUCgQUAxNjB6NzFOwG0v	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV7M{G4Nkc,OTR3OUOxPFI9N2F-
TF1	M1GNmZ2dmO2aX;uJIF{e2G7		NUjVU25JOjBibXnudy=>	NVW4ZZdjUW6qaXLpeIlwdiCxZjDKRWszKGmwIHj1cYFvKFSIMTDj[YxteyCjc4Pld5NmCCjczDpcohq[mm2aX;uJI9nKEWSTz3pcoR2[2WmIGPURXQ2KHCqb4PwbI9zgWyjdHnvckBqdmO3YnH0[YQhm:{IEKwJI1qdnNicILpc5IhfG9iRWDPMYlvHWldHnvckBuWG\|dYLl[EBi SncjCzNEB1dyB2NTDtbY5{NCCHQ{WwJF0hOC5yOUOg{txONg>?	M2LeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ{Nkm4NFg1Lz5{Mk[5PFA5PDxxYU6=
TF1	NHjNcnNHfW6ldHnvckBie3OjeR?=		NYrrfWdDOjBibXnudy=>	Mn3RTY5pcWKrdHnvckBwiCMQVuyJIlvKGi3bXHuJHRHOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGVRVy2rbnT1Z4VlKFOWQWS1JJBpd3OyaH;yfYxifGmxbjDpcoN2[mG2ZXSg[o9zKDJyIH3pcpMhm:ubH;3[YQh[nliSVy2JINp[WyuZX7n[UBnd3JiM{CgcYlveyxiRVO1NEA:KDBwMEmzJO69VS5?	Mmf3QIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NUmyNVQoRjJ\|NkW5NlE1RC:jPh?=
PBMC	M2nOUWZ2dmO2aX;uJIF{e2G7			NWnF[4lMUW6qaXLpeIlwdiCxZjDKRWsyKGmwIHj1cYFvKFCETVOgZ4VtdHNiYYPz[ZN{WRiYYOgbY5pcWKrdHnvckBwiCLTD22MYlvHWlZXSgUWNROSC\|ZXPy[ZRqd25uIFnDOVAhRSByLkC5OUDPxE1w	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{N{SyN{c,OjZ7Mke0NlM9N2F-
TF1	M1rvN2Z2dmO2aX;uJIF{e2G7		NGnhS3QzKGi{cx?=	NGHTR2VKdmirYnn0bY9vKG:oIFrBT\|IhcW5iR13DV2Yue3SrbYXsZZRmCCqdX3hckBVTjFiY3XscJMh[XO\|ZYPz[YQh[XNic4XwdJJme3Orb36gc4YhW1SDVEWgdIhwe3Cqb4L5cIF1cW:wIIDy[Ylv[3WkYYTl[EBnd3JiMjDodpMhm:ubH;3[YQh[nliR13DV2Yhe3SrbYXsZZRqd25iZn;yJFUxKG2rboOgZpkhTkGFUzDy[YFlXJiYX7hcJl{cXNuIFnDOVAhRSByLkC5OUDPxE1w	M4PGflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ5MUOwN\|U6Lz5{N{GzNFM2QTxxYU6=
TF1	NV:yOZl[TnWwY4Tpc44h[XO\|YYm=			NXHqc2xKUW6qaXLpeIlwdiCxZjDKRWszKGmwIFXQU{1{fGmvdXzheIVlKGi3bXHuJHRHOSClZXzsd{BmgHC{ZYPzbY5oKHO2YXLsfUBqdnSnZ4LheIVlKGKndHGtcIFkfGGvYYPlJJJmeG:{dHXyJIdmdmVidX7k[ZIh[2:wdILvcEBwiCVVFHUOUBzXOyb37z[UBmdGWvZX70d{BqdiCrboTldoZmem:wIILl[5Vt[XSxcomg[oFkfG:{IEGg[4VvSCycn;tc5RmeiCkeTDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTCwMlExPyEQvF2u	M4HZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ7MUW2NVM3Lz5{OUG1OlE{PjxxYU6=
Sf9	NYrle3hlTnWwY4Tpc44h[XO\|YYm=			M3L5c2lvcGmkaYTpc44hd2ZiR2PUMZRi2enZDDoeY1idiCMQVuxJINifGGueYTpZ{Bld22jaX6g[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMUGg{txONg>?	NHzRfFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{MUGwOVcyOSd-MkGxNFU4OTF:L3G+
T-cells	NFrYfZRHfW6ldHnvckBie3OjeR?=			MoITY5pcWKrdHnvckBwiCjbHzv[4VvcWNiY3XscJMue3SrbYXsZZRmCCycn;sbYZmemG2aX;uJIlvKG2xdYPlJHQh[2WubIOgZpkhdWm6ZXSgcJlueGixY4n0[UBzWGldHnvckBuXSqb3SsJGlEPTBiPTCwMlEyPSEQvF2u	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV7M{G4Nkc,OTR3OUOxPFI9N2F-
ME180	M1uyPWZ2dmO2aX;uJIF{e2G7			MXXJcohq[mm2aX;uJI9nKEqDS{GgbY4hUUx4LYP0bY12dGG2ZXSgbJVu[W5iTVWxPFAh[2WubIOg[ZhxemW\|c3nu[{B{fGGkbImgbY51We{YYTl[EBjXSjLXzhZ5RidWG\|ZTDy[ZBwenSncjDn[Y5mKHWwZHXyJINwdnS{b3ygc4Yhe2m\|LXnu[JVkcWKuZTDlcIVuW62IHL5JIZtfW:{ZYPj[Y5kSCjc4PhfUwhUUN3MDC9JFAvOTJ2IN88UU4>	NYfOTI9GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxOVYyOzZpPkK5NVU3OTN4PD;hQi=>
CTLL-2	MXTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M{Fc\|czKGi{cx?=	MoPwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDJUE0zNXO2aX31cIF1WRibX;1d4UhS1SOTD2yJINmdGy\|IHX4dJJme3OrbnegTmFMOS:MQVuzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeTygTWM2OCB;IECuNVMzKM7:TT6=	NFXtfXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9zOUe2NlI{QCd-MUm3OlIzOzh:L3G+
HT2	M{TmZ2dmO2aX;uJIF{e2G7			NEFUlJKdmirYnn0bY9vKG:oIFrBT\|MhcW5ibX;1d4UhUFR{IHPlcIx{KGG\|c3Xzd4VlKGG\|IIP1dJBzXO\|aX;uJI9nKGOnbHyg[5Jwf3SqLDDJR\|UxKD1iMD6xOVYh\|ryPLh?=	M4XZU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzJ5N{exNVgxLz5{N{e3NVE5ODxxYU6=
DND/L12	MV;GeY5kfGmxbjDhd5NigQ>?		MnfjN\|AhdWmwcx?=	NFXeVBKdmirYnn0bY9vKG:oIFrBT\|MhcW5iaIXtZY4hTE6GL1yxNkBkWyuczDh[pRmeiB\|MDDtbY5{KGK7IHz1Z4lnXKjc3WgZZN{[XliaX6gdJJme2WwY3Wgc4YhcHWvYX6gd4VzfW1iYXzieY1qdixiSVO5NEA:KDBwMU[g{txONg>?	MlHQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR3OUOxPFIoRjF2NUmzNVgzRC:jPh?=
T-cells	MlzwSpVv[3Srb36gZZN{[Xl?			NYmyc4l5UW6qaXLpeIlwdiCxZjDKRWszNzFiaX6gbJVu[W5iVDDj[YxteyCneIDy[ZN{cW6pIFPEN{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlHVmejbX3hMZN1cW23bHH0[YQhW1SDVEGgdIhwe3Cqb4L5cIF1cW:wLDDJR\|UxKD1iMD6xO{DPxE1w	MnfFQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3NEC2OFgoRjJ\|NUSwOlQ5RC:jPh?=
insect	MXrGeY5kfGmxbjDhd5NigQ>?			NVXQUJhrUW6qaXLpeIlwdiCxZjDHV3QufGGpZ3XkJHR6czJiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyC3c3nu[{A{PSC3TTDBWHAtKEmFNUCgQUAxNjF5NjFOwG0v	NXz0O5VkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxOVU3ODVpPkKxNVU2PjB3PD;hQi=>
Ba/F3	NGLIeFBHfW6ldHnvckBie3OjeR?=		M4DIT\|YxKG2rboO=	MYnJcohq[mm2aX;uJI9nKFSHTD3meZNmCCMQVuyJIV5eHKnc4Pl[EBqdiCEYT;GN{BkWyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGPURXQ2KHCqb4PwbI9zgWyjdHnvckBi SncjC2NEBucW6\|IHL5JGFteGijU3Py[YVvKGG\|c3H5MEBKSzVyIE2gNE4zPjVizszNMi=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB6N{e1NEc,OjJyOEe3OVA9N2F-
TF1	NFrYWJdHfW6ldHnvckBie3OjeR?=			NXvGbGxJUW6qaXLpeIlwdiCxZjDKRWszKGmwIHj1cYFvKFSIMTDj[YxteyCjc4Pld5NmCCjczDzeZBxemW\|c3nvckBwiClZXzsJIdzd3e2aDygTWM2OCB;IECuNlc2OSEQvF2u	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd5MUG4NEc,Ojd5N{GxPFA9N2F-
CD34+	NYq3eYh[TnWwY4Tpc44h[XO\|YYm=			NH3uUI5KdmirYnn0bY9vKG:oIFrBT\|IhcG:vb3TpcYVzKGmwIHj1cYFvKEOGM{SrJINmdGy\|IIPwbYtmCCrboTvJIh2dWGwIIfoc4xmKGKub3;kJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gSXBQNWmwZIXj[YQhW1SDVD21JJBpd3OyaH;yfYxifGmxbjDwdoVqdmO3YnH0[YQhm:{IES1JI1qdnNiZn;scI94WRiYomgSXBQKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFE2KG2rboOgZpkhTkGFUzDhcoFtgXOrczygTWM2OCB;IECuN\|AzKM7:TT6=	NWDERY9kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0NVc2OzNpPkK0OFE4PTN\|PD;hQi=>
HUO3	MXrGeY5kfGmxbjDhd5NigQ>?		NFzh[JE1KGSjeYO=	MVHJcohq[mm2aX;uJI9nKGi3bXHuJGdONUOVRj3pcoR2[2WmIIDyc4xqmW{YYTpc44hcW5iaIXtZY4hUFWRMzDj[YxteyCjc4Pld5NmCCjczDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gZYZ1XJiNDDkZZl{KGK7IIPjbY51cWyuYYTpc44h[2:3boTpcoctKEmFNUCgQUAxNjN{NDFOwG0v	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV7M{G4Nkc,OTR3OUOxPFI9N2F-
HU03	NV[5WJhKTnWwY4Tpc44h[XO\|YYm=		M1f2N\|czKGi{cx?=	NGX1bWFKdmirYnn0bY9vKG:oIFfNMWNUTi2rbnT1Z4VlKGi3bXHuJGhWODNiY3XscJMheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliW{PIYZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHHzd4F6NCCLQ{WwJF0hOC5\|MkSg{txONg>?	NYrHWXNXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNFU4OTFpPkKxNVA2PzFzPD;hQi=>
BAF3	MWDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M3HpW\|czKGi{cx?=	NEniUHJCdnSrcILvcIlnXKjdHn2[UBi[3Srdnn0fUBi2GrboP0JI1wfXOnIFLBSlMh[2WubIOg[ZhxemW\|c3nu[{BVTUxvSlHLN{BscW6jc3WgZYZ1XJiN{KgbJJ{KGK7IHHsZY1ieiCkbIXlJIF{e2G7LDDJR\|UxKD1iMD61O{DPxE1w	NUezNXQ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OlIzOzhpPkG5O\|YzOjN6PD;hQi=>
T-cells	NIezZWFHfW6ldHnvckBie3OjeR?=		NEnRfJY{KGSjeYO=	NFrQeGxKdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDv[kBKVDJvYXP0bZZifGWmIHHu[EBETDNiYX7kJGNFOjhiYX70bYJwHlvc4TpcZVt[XSnZDDtc5V{SCFREStdI9{cXSrdnWgWEBkWyuczDh[pRmeiB\|IHThfZMh[nliWGTUJIF{e2G7LDDJR\|UxKD1iMD62N{DPxE1w	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODR4MEi0Nkc,OzB2NkC4OFI9N2F-
NK92	M4fmRmZ2dmO2aX;uJIF{e2G7		M{GRVIxKG2rboO=	MVfJcohq[mm2aX;uJI9nKFSS{KgbY4hcHWvYX6gUms6OiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNOTJvaX7keYNmCCVVFHUOEBxcG:\|cHjvdplt[XSrb36gbY5kfWKjdHXkJIZweiB{MDDtbY5{KG[xbHzve4VlKGK7IFnMNVIh[2ijbHzlcodmKG[xcjC0OUBucW6\|LDDFR\|UxKD1iMD63NUDPxE1w	MkTmQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NUmyNVQoRjJ\|NkW5NlE1RC:jPh?=
TF1	MXTGeY5kfGmxbjDhd5NigQ>?			MVLJcohq[mm2aX;uJI9nKEmOMz3pcoR2[2WmIIDyc4xqmW{YYTpc44hd2ZiVF[xJINmdGy\|LDDJR\|UxKD1iMD64JO69VS5?	NEDYWpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9zNkmzOFQ2Pyd-MU[5N\|Q1PTd:L3G+
UT7	NX3DVFN5TnWwY4Tpc44h[XO\|YYm=			NGHy[nFKdmirYnn0bY9vKG:oIFrBT\|IhcW5iaIXtZY4hXVR5IHPlcIx{KGG\|c3Xzd4VlKGG\|IIP1dJBzXO\|aX;uJI9nKEWSTz3zeIlufWyjdHXkJHNVSVR3IIDoc5NxcG:{eXzheIlwdiCkeTDBcJBp[VOlcnXlckBie3OjeTygTW5JKD1iMT6xNkDPxE1w	NUD0SnJHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zO\|I3PTNpPkK2N\|czPjV\|PD;hQi=>
Ba/F3	MV3GeY5kfGmxbjDhd5NigQ>?		M{fVdlYxKG2rboO=	MmDLTY5pcWKrdHnvckBwiCWRVyt[pV{WRiVGnLNkBmgHC{ZYPz[YQhcW5iQnGvSlMh[2WubIOgZZN{XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDTWGFVPSCyaH;zdIhwenmuYYTpc44h[W[2ZYKgOlAhdWmwczDifUBCdHCqYWPjdoVmdiCjc4PhfUwhUUN3MDC9JFEvOiEQvF2u	Ml7rQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOEe3OVAoRjJ{MEi3O\|UxRC:jPh?=
T-cells	NXOOpVOTnWwY4Tpc44h[XO\|YYm=		NHXCNos4OiCqcoO=	NX65e4NiUW6qaXLpeIlwdiCxZjDKRWs{KGmwIILheEB{eGynbn;jfZRq[yCWIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBKVC1{LXnu[JVkWRiY3XscEBxem:uaXldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSBzLkKg{txONg>?	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF\|OUW3OUc,OzBzM{m1O\|U9N2F-
SZ4	NYPvbHJbTnWwY4Tpc44h[XO\|YYm=			MVPJcohq[mm2aX;uJI9nKEqDS{OgbY4hcHWvYX6gV3o1KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDJUFIue3SrbYXsZZRmCCVVFHUOUBxcG:\|cHjvdplt[XSrb36gdJJmcW6ldXLheIVlKG[xcjCxJIhzKG[xbHzve4VlKGK7IFnMNkB{fGmvdXzheIlwdiCjbnSgcYVie3W{ZXSgZYZ1XJiMUWgcYlveyCkeTDNV2Qh[XO\|YYmsJGlEPTBiPTCxMlIyKM7:TT6=	NIPiflA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9\|MES2NFg1Oid-M{C0OlA5PDJ:L3G+
BAF3	MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NFrKZYk4OiCqcoO=	M2jS[GFvfGmycn;sbYZmemG2aYlJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlHGN{BkWyuczDlfJBzXO\|aX7nJHRGVC2MQVuyJItqdmG\|ZTDh[pRmeiB5MjDodpMh[nliYXzhcYFzKGKudXWgZZN{[XluIFnDOVAhRSBzLkW3OEDPxE1w	M2nRTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzF7N{[yNlM5Lz5zOUe2NlI{QDxxYU6=
HEL	MYHGeY5kfGmxbjDhd5NigQ>?		NFHLdpUyKGi{	NGPsW2hKdmirYnn0bY9vKG:oIFrBT\|IhXjZzN1[gcZV1[W62IHnuJIh2dWGwIFjFUEBkWyuczDh[pRmeiBzIHjyMEBKSzVyIE2gOE44OjRizszNMi=>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd5MUG4NEc,Ojd5N{GxPFA9N2F-
Jurkat	Mn7iSpVv[3Srb36gZZN{[Xl?		MX:yOEBpenN?	MkToTY5pcWKrdHnvckBwiCjboTpMWNFOy:jboTpMWNFOjhvaX7keYNmCCLTEKgdJJwHWldHnvckBqdiCqdX3hckBLfXKtYYSgZ4VtdHNiYX[ZIhOjRiaILzJIJ6KHOlaX70bYxt[XSrb36gZ492dnSrbnesJGlEPTBiPTC3Mlg1KM7:TT6=	M{C0b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzF2NUmzNVgzLz5zNEW5N\|E5OjxxYU6=
YT	MWfGeY5kfGmxbjDhd5NigQ>?	NILCU5M{OCCwZz;tcC=>		M4LScWlvcGmkaYTpc44hd2ZiSVyyMYlvHWlZXSgTmFMOyCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hYVRiY3XscJMh[XRiM{CgcocwdWxiYomgbY1ufW6xYnzveJRqdmdiYX7hcJl{cXN?	NYGwblBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS1PVMyQDJpPkG0OVk{OTh{PD;hQi=>
YT	MnnGSpVv[3Srb36gZZN{[Xl?	M3Hq[FMxKG6pL33s		NV7P[\|JSUW6qaXLpeIlwdiCxZjDJUFIucW6mdXPl[EBUXEGWNVGgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIGnUJINmdGy\|IHH0JFMxKG6pL33sJIJ6KGmvbYXuc4Jtd3S2aX7nJIFv[Wy7c3nz	MknjQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR3OUOxPFIoRjF2NUmzNVgzRC:jPh?=
YT	NEn0bJNHfW6ldHnvckBie3OjeR?=	NGuUXk{OCCwZz;tcC=>		Mk[5TY5pcWKrdHnvckBwiCLTEKtbY5lfWOnZDDTWGFVPUJicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKFmWIHPlcIx{KGG2IEOwJI5oN22uIHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m\|	M3mzWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzF2NUmzNVgzLz5zNEW5N\|E5OjxxYU6=
NK-cells	NYnGOlFUUW2vdX7vd5VxeHKnc4PpeoUh[XO\|YYm=	MYmxJJRwKDVibXevb4c>	MlfoOEB4WWtcx?=	Ml3KTY1ufW6xc4XwdJJme3OrdnWgZYN1cX[rdImgbY4hdmGrdnWgZ5lvd22xbHf1d{Bud26tZYmgZZN{XO\|ZXSgZZMhW[oZXP0JI9vKEOGMz3DSFE3MyCQSzDj[YxteyCjdDCxJJRwKDVibXevb4ctKHCxIHvdkA1KHenZXvz	M1XUV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1mC6wY3LpMo5tdS6waXiu[493NzF2NUmzNVgzLz5zNEW5N\|E5OjxxYU6=
T-cells	MUfGeY5kfGmxbjDhd5NigQ>?	M4r0fVUhfG9iNUCwJI5O	NXnNToE6OSCqch?=	M2jsU2lvcGmkaYTpc44hd2ZiSVyyMYlvHWlZXSgV5RifDVicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEOGNDugWEBkWyuczDheEA2KHSxIEWwNEBvVSCjZoTldkAyKGi{IHL5JHdme3Sncn6gZoxwfA>?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e1Okc,OTlyNUO3OVY9N2F-
SUM149PT	MXLGeY5kfGmxbjDhd5NigQ>?	MYqzJJVO	MoD1NVYhcHK\|	M3u1PGlvHWldHnvckBwiCSVGDOOkBqdiCqdX3hckBUXU1zNEnQWEBkWyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGPURXQ{KHCqb4PwbI9zgWyjdHnvckBifCB\|IIXNJIFnfGW{IEG2JIhzeyCkeTDX[ZN1XKwIHLsc5R1cW6pIHHuZYx6e2m\|IHnuJJBzXOnbnPlJI9nKHCncohcoFl[XSn	NXXRRW9JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5O\|gyOTJpPkK0PVc5OTF{PD;hQi=>
Hs578T	NWDzT41yTnWwY4Tpc44h[XO\|YYm=	M3rQPFMhfU1?	NW2NXpoOTZiaILz	MkTKTY5lfWO2aX;uJI9nKFCWUF62JIlvKGi3bXHuJGh{PTd6VDDj[YxteyCjc4Pld5NmCCjczDpcohq[mm2aX;uJI9nKFOWQWSzJJBpd3OyaH;yfYxifGmxbjDheEA{KHWPIHHmeIVzKDF4IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5oKGGwYXz5d4l{KGmwIIDy[ZNmdmOnIH;mJJBmen[jbnHkZZRm	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl5OEGxNkc,OjR7N{ixNVI9N2F-
T-cells	NXLiWoJVTnWwY4Tpc44h[XO\|YYm=	Mn3vOVAhfG9iM{CwJI5O	NIjONnEyKGi{	MkDOTY5pcWKrdHnvckBwiCMQVuxM2pCUzNiaX6gbJVu[W5iQ1S0JJBwe2m2aYlJHQh[2WubIOgZZN{XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDJUFQue3SrbYXsZZRmCCVVFHUOkBxcG:\|cHjvdplt[XSrb36gZZQhPTBidH:gN\|AxKG6PIIDy[Ylv[3WkYYTl[EBnd3JiMTDodkBnd2yub4fl[EBjgSCLTD20JJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFMxKG2rboOgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>?	NICwWVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{OUi1NlA3QCd-Mkm4OVIxPjh:L3G+
T-cells	NXzYfXZ1TnWwY4Tpc44h[XO\|YYm=	M4L3S\|UxKHSxIEOwNEBvVQ>?	MnXENUBpeg>?	M3Hnb2lvcGmkaYTpc44hd2ZiSlHLNU9LSUt\|IHnuJIh2dWGwIFPEOEBxd3OrdHn2[UBVKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gTWwzNXO2aX31cIF1WRiU2TBWFUheGixc4Doc5J6dGG2aX;uJIF1KFS7cj22PVUhemW\|aXT1[UBifCB3MDD0c{A{ODBibl2gdJJmcW6ldXLheIVlKG[xcjCxJIhzKG[xbHzve4VlKGK7IFnMMVIhe3SrbYXsZZRqd25ibXXhd5VzWRiYX[ZIhOzBibXnud{BjgSCrbX31co9jdG:2IHHuZYx6e2m\|	NGK4XIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{OUi1NlA3QCd-Mkm4OVIxPjh:L3G+
T-cells	MnnLSpVv[3Srb36gZZN{[Xl?	M1jUbF4{ODBibl2=	NVzsWYRROSCqch?=	M4XqU2lvcGmkaYTpc44hd2ZiSlHLNU9LSUt{L2TZT\|IhcW5iaIXtZY4hS0R2IIDvd4l1cX[nIGSgZ4VtdHNiYYPz[ZN{WRiYYOgbY5pcWKrdHnvckBwiCLTE[td5RqdXWuYYTl[EBUXEGWMzDwbI9{eGixconsZZRqd25iYYSgQlMxOCCwTTDwdoVqdmO3YnH0[YQhm:{IEGgbJIhm:ubH;3[YQh[nliSVytOkB{fGmvdXzheIlwdiCvZXHzeZJmCCjZoTldkA{OCCvaX7zJIJ6KGmvbYXuc4Jtd3RiYX7hcJl{cXN?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh3MkC2PEc,Ojl6NUKwOlg9N2F-
TALL-1	M3r2NWZ2dmO2aX;uJIF{e2G7	NWXieGpzOSC3TR?=	M1vjZ\|MhcHK\|	MWJcohq[mm2aX;uJI9nKEqDS{OgbY4hcHWvYX6gWGFNVC1zIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhUUxvMjDpcoR2[2WmIGPURXQ2KHCqb4PwbI9zgWyjdHnvckBifCBzIIXNJJBzWmwY4XiZZRmCCob4KgN{BpenNiZn;scI94WRiYomgTWwuOiCrbnT1Z5Rqd25ibXXhd5VzWRiYX[ZIhOzBibXnud{BjgSCrbX31co9jdG:2dHnu[y=>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3OEWyNUc,OjZ{NUi1NlE9N2F-
BA/F3	M2W0SmZ2dmO2aX;uJIF{e2G7	NITl[ow{ODBibl2=	MYWzJIhzew>?	MlxTY5pcWKrdHnvckBwiCMQVuzJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDv[kBUXEGWNTDwbI9{eGixconsZZRqd25iYYSgN\|AxKG6PIHHmeIVzKDNiaILzJIJ6KGmvbYXuc4Jtd3S2aX7nJIFv[Wy7c3nz	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3OEWyNUc,OjZ{NUi1NlE9N2F-
OCL-AML5	NIPXeIFHfW6ldHnvckBie3OjeR?=	NFwWmgyKHWP	MVizJIhzew>?	NXrpcmNQUW6qaXLpeIlwdiCxZjDKRWszKGmwIHj1cYFvKE:FTD3BUWw2KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gS20uS1OIIHnu[JVkWRiU2TBWFUheGixc4Doc5J6dGG2aX;uJIF1KDFidV2gdJJmcW6ldXLheIVlKG[xcjCzJIhzeyCob3zsc5dmCCkeTDHUU1EW0ZiaX7keYN1cW:wIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMh[nliaX3teY5w[myxdITpcoc>	NWnLcZlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOVg2OjFpPkK2NlU5PTJzPD;hQi=>
BA/F3	MloRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mkj4O\|IhcHK\|	MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegWGVNNUqDS{OgZYZ1XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKg[4xwKGG\|c3H5	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJmj1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ3OEWyNUc,OjZ{NUi1NlE9N2F-
BA/F3	M3nTO2Z2dmO2aX;uJIF{e2G7	MWqxJJVO	NUHZdWRWOyCqcoO=	NHvzcXpKdmirYnn0bY9vKG:oIFrBT\|MhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYSgNUB2VSCycnXpcoN2[mG2ZXSg[o9zKDNiaILzJIZwdGyxd3XkJIJ6KHC3bHzkc5dvKHerdHigd5RzXC2YYp[IlvKGKnYXTzJIJ6KGmvbYXuc4Jtd3S2aX7nJIFv[Wy7c3nz	MmMQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NUi1NlEoRjJ4MkW4OVIyRC:jPh?=
Huh7	NHKWo9HfW6ldHnvckBie3OjeR?=	MnLWNVAhfU1?	NWHtcHFyOzBibXnudy=>	NGLZTXZKdmirYnn0bY9vKG:oIGT5b\|IhcW5iaIXtZY4hUHWqNzDj[YxteyCjc4Pld5NmCCjczDy[YR2[3Srb36gc4YhUU[QYXzwbIE2NWmwZIXj[YQhW1SDVEOgdIhwe3Cqb4L5cIF1cW:wIHH0JFExKHWPIIDy[U1qdmO3YnH0[YQhm:{IEOwJI1qdnNiYnXmc5JmKEmITnHsdIhiPSC\|dHnteYxifGmxbjDmc5IhOzBibXnud{BucW6\|IHL5JIludXWwb3Lsc5R1cW6p	Mn;TQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{M{GxOVkoRjJ4MkOxNVU6RC:jPh?=
Huh7	NUESVlRTnWwY4Tpc44h[XO\|YYm=	M4G4RlExKHWP	NHfGWos{OCCvaX7z	Mlm4TY5pcWKrdHnvckBwiCWeXuyJIlvKGi3bXHuJGh2cDdiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJIJie2GuIHzleoVtKFOWQWSzJJBpd3OyaH;yfYxifGmxbjDheEAyOCC3TTDh[pRmeiB\|MDDtbY5{KGK7IHntcZVvd2Kub4T0bY5o	NFzZTnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJuWRwbnPibU5vdG1wbnnoModwfi9{NkKzNVE2QSd-Mk[yN\|EyPTl:L3G+
Huh7	MlpSpVv[3Srb36gZZN{[Xl?	M4XWRlEhfU1?	NGHrO2c{OCCvaX7z	NF ZYNKdmirYnn0bY9vKG:oIGT5b\|IhcW5iaIXtZY4hUHWqNzDj[YxteyCjc4Pld5NmCCjczDy[YR2[3Srb36gc4YhUU[QYXzwbIE2NWmwZIXj[YQhW1SDVEOgdIhwe3Cqb4L5cIF1cW:wIHH0JFEhfU1icILlMYlv[3WkYYTl[EBnd3JiM{CgcYlveyCkZXvdoUhUU[QYXzwbIE2KHO2aX31cIF1cW:wIHvdkA{OCCvaX7zJI1qdnNiYomgbY1ufW6xYnzveJRqdmd?	MnxQIEhfGG{Z3X0QUdg[myjbnunJIhzWZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{M{GxOVkoRjJ4MkOxNVU6RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	JAK3 / STAT5 / p-STAT5 ; PubMed: 27732937Oncotarget The following cell lines: EBV-negative B cell line (BJAB), EBV-transformed lymphoblastoid cell line (LCL), EBV-negative T cell lines (Jurkat and MOLT4), EBV-positive T cell lines (SNT15 and SNT16), EBV-negative NK cell line (KHYG1), and EBV-positive NK cell lines (KAI3 and SNK6), were treated without (−) or with (+) 1 μM tofacitinib for 24 h and cell lysates were then immunoblotted for the indicated proteins. LMP1 / EBNA1 / BZLF1 ; PubMed: 27732937Oncotarget SNT13, SNT15, SNT16, KAI3 and SNK6 cell lines were treated with 5 μM tofacitinib for 48 h, and cell lysates were immunoblotted for LMP1, EBNA1 and BZLF1. Actin was blotted as a loading control. JAK3 / p-JAK3 / STAT3 ; PubMed: 26082451Blood CTCL cell lines were subjected to western blot (tofacitinib 10, 100, 200 nM) (G) after 48 hours of treatment.	27732937 26082451
Growth inhibition assay	Cell number ; PubMed: 27732937Oncotarget BJAB, LCL, Jurkat, SNT15, KHYG1 and KAI3 cells were treated with the indicated concentrations of tofacitinib, and viable cells were counted at the indicated times using the trypan blue exclusion test. Values are means ± SE of the results from triplicate experiments. *P < 0.05 as compared with DMSO-treated cells.	27732937

In vivo

In a murine model of heterotopic heart transplantation (DBA2 donor heart into C57/BL6 host), CP-690550 results in a dose-dependent increase in survival of transplanted hearts.The EC50 (drug concentration in blood at which 50% of mice will maintain their graft for >28 days) to be ~60 ng/mL.CP-690550 prevents rejection of allogeneic kidneys in nonhuman primate (NHPs, macaca fascicularis) (MST of 62 and 83 days for the 50 to 100 ng/ml groups and 200 to 400 ng/ml groups, respectively). ^[1] Mice chronically dosed with CP-690550 (1.5-15 mg/kg/day) demonstrates dose and time-dependent alterations in lymphocyte subsets when examined by flow cytometry. The most dramatic change observed is a 96% reduction in splenic NK1.1+TCRb-cell numbers following 21 days of treatment. Delayed-type hypersensitivity (DTH) responses in sensitized mice are reduced in a dose-dependent manner following treatment with CP-690550 (1.87–30 mg/kg, s.c.). Extended survival of neonatal Balb/c hearts implanted into the ear pinna of MHC mismatched C3H/HEN mice is observed with CP-690550 monotherapy (10–30 mg/kg/day), but improved upon combination with cyclosporin (10 mg/kg/day). ^[2]

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