Selleckchem/RIPA-56/S6511
商品编号:
S6511
市场价:
¥13940.00
美元价:
8364.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | RIPA-56isahighly-potent,selective,andmetabolicallystableRIP1(RIPK1)inhibitor. | ||
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Targets |
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Invitro | RIPA-56showsefficientinhibitionofRIP1kinaseactivity,withanIC50of13nM.ItshowednoinhibitionofRIP3kinaseactivityata10µMconcentration.RIPA-56doesnotinhibitIDOactivityataconcentrationof200µM,whichrepresentsanestimated10,000-foldselectivitywindowbasedontheRIP1ADP-Gloactivityof13nM[1]. | ||
Invivo | RIPA-56hasanimpressivePKprofileinmice,witha3.1hhalf-life,22%oralbioavailABIlity(PO),and100%bioavailabilityfromintraperitonealinjection(IP).RIPA-56hasgreatabilityintransportingacrossbloodbrainbarrier.IntheSIRSmicediseasemodel,RIPA-56efficientlyreducedtumornecrosisfactoralpha(TNFα)-inducedmortalityandmulti-organdamage[1]. |
品牌介绍
Selleck Chemicals是世界领先的高性能的生命科学产品供应商之一,主要致力于提供MAPK和PI3K/Akt/mTOR等上百个信号通路的高特异性小分子抑制剂。Selleck 产品线补充非常及时,可以提供行业内最新的抑制剂类产品。同时Selleck也是专业的高通量筛选抑制剂分子库、API、天然产物和多肽供应商。